Atractylodes Rhizome has dampness, spleen, and rheumatism. Indications of wet resistance in the coke, dampness, dampness, swelling of the foot and knee, weakness, weakness, bird night blindness. "Pearl sac" day: "To stomach and spleen, the various wet swollen not this can not be removed." "Compendium of Materia Medica" said: "Clean phlegm and stay in the drink ... ... and spleen wet, turbid lees, diarrhea, intestinal wind "The Newly Revised Materia Medica" says it can "make urinary urination."
(1) Adjusting Gastrointestinal Motility Atractylodes Rhizome Decoction and Atractylodes roxburghii extract can relieve acetylcholine-induced isolated intestinal fistula in a certain dose range, but it has certain antagonistic effects on epinephrine-induced inhibition of small intestinal motility. . Atractylodes ethanol extract can also protect rats from gastric muscle smooth muscle spasm induced by acetylcholine and barium chloride, but has slight excitatory effect on normal rat gastric smooth muscle. The acetone extract of Atractylodes lancea, β-eucalyptus and Maofu alcohol had a strong antagonistic effect on the contraction of small intestine in rats induced by methacholine, Ca2+ and electrical stimulation. Atractylodin extract from Atractylodes lucidum promotes mice's charcoal advancement. The "small spleen-deficiency diarrhea" rat model developed by Senna Decoction had an effect of promoting small intestine advancing exercise, and the herb decoction had obvious antagonistic effects.
(2) Anti-ulcer herb has strong anti-ulcer effect. The experiments showed that Atractylodes lancea and Atractylodes lancea have a strong inhibitory effect on pylorus ligating ulcers, pyloric ligation-aspirin ulcers, and stress ulcers. Both atractylodes lanceolata can significantly inhibit ulcers, gastric juice volume, total acidity, and total digestion of animals. Ability and gastric muغير مجاز مي باشدal damage. According to the study, there are two main aspects of the anti-ulcer action mechanism of Cangzhu:
1Inhibiting gastric acid secretion: Atractylodes lucidum in the volatile oil of Atractylodes lancea can inhibit the release of steroid hormones and reduce the stimulation of steroid hormones on gastric acid secretion. β-eucalyptus contained in Atractylodes lancea has anti-H2 receptor function and can inhibit gastric acid secretion. , And anti-corticoid hormone on the stimulation of gastric acid secretion.
2 to enhance the role of gastric muغير مجاز مي باشدal protection: North Atractylodes can increase gastric muغير مجاز مي باشدal blood flow, glyغير مجاز مي باشدides extracted from Atractylodes can promote gastric muغير مجاز مي باشدa repair, Atractylodes macrocephala (A.japonica) can also significantly increase the aminohexose in the gastric juice and The content of the muغير مجاز مي باشدa, thereby enhancing the protective effect of gastric muغير مجاز مي باشدa.
(3) Hepatoprotective herb and β-eucalyptus, furazoliol and atractylone have significant preventive effects on CCL4 and D-galactose induced cultured rat liver cell damage. In addition, Atractylodes decoction has a significant role in the promotion of liver protein synthesis in mice.
(4) Antibacterial Atractylodes extract has the effect of eliminating drug-resistant R. flexneri R plasmid, which can reduce the development of bacterial resistance. The herb was soaked in 95% ethanol for 10 hours. The herb was removed, placed on the floor of the operating room to be sterilized, and ignited until it turned into ash. After sterilization, the number of colonies in the air before disinfection was significantly reduced. However, early in vitro studies did not find that the herb decoction has a significant antibacterial effect.
effect
(1) Effect on Blood Sugar Aorta decoction administered intragastrically or subcutaneously with alcoholic inhaler can increase the blood sugar level of normal rabbits, but it can also reduce blood gluغير مجاز مي باشدe level in rabbits with alloxan-induced diabetes. Aqueous extracts of Cangzhu can reduce the hyperglycemia level induced by streptomycin in rats. Studies have suggested that the active ingredient of Atractylodes macrocephala and adenine nucleotides play a competitive inhibitory role on the same mitochondria, thereby inhibiting the oxidative phosphorylation in cells and interfering with the energy transfer process.
(2) Anti-hypoxia In mice model of hypoxia induced by potassium cyanide, aeruginosa acetone extract 750mg/kg gavage, can significantly prolong the survival time of mice, and reduce the relative mortality of mice. The main anti-hypoxia activity of the herb is β-eucalyptus.
(3) The central inhibition of Atractylodes lancea, Atractylodes lancea, β-eucalyptus, and furazolidone have a sedative effect on mice and can inhibit the spontaneous activity of mice. Atractylodes extract and volatile oil, a small dose of the spinal cord hyperreflexia, a larger dose was inhibited, and eventually caused respiratory paralysis and died. The extract of Atractylodes Rhizome and Atractylodes lancea can enhance the effect of barbiturate sleep. Its pharmacologically active ingredients are mainly β-eucalyptus and Maofu alcohol.
(4) The anti-tumor atractylodes volatile oil, Maoshu alcohol and β-eucamolol l00mg/ml had inhibitory effect on esophageal cancer cells in vitro, among which, the effect of the chitosan alcohol was strong.
(5) to promote bone calcification Cangzhu contains calcium and phosphorus absorption related to vitamin D, its volatile oil has to promote bone calcification. Northern atractylodes essential oil can alleviate symptoms to a certain extent in white broiler chicks suffering from rickets.
(6) Effects on the cardiovascular system Atractylodes Rhizome has a mild inhibitory effect on the iliac crest, and mildly dilated blood vessels on the zygomatic hindlimbs. A small dose of intravenous injection of Atractylodes lancea makes the blood pressure of the rabbit rise slightly, and the high dose reduces the blood pressure.
In summary, the pharmacological effects associated with the dampness and spleen function of Cangshu include adjusting gastrointestinal motility, anti-ulcer, and liver protection. Antibacterial and so on. The main active ingredient of herb is the volatile oil represented by β-eucalyptus and Maofu alcohol. The effect of herb on blood sugar. Anti-hypoxia, central inhibition, anti-tumor, bone calcification, and effects on the cardiovascular system are the modern research advances in its pharmacological effects.
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